Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation recombinant diagnostic ...

AQP4 antibodies of the IgM class are observed in 10% of AQP4-Ab-positive patients with NMO. [54] In general, IgM antibodies are more potent activators of complement than are IgG antibodies ...

Satralizumab performed even better in patients with a specific biomarker – anti-aquaporin-4 (AQP4) antibody – with a 74% reduction in relapses risk compared to placebo. AQP4 antibodies ...