For the 26S proteasome, this usually involves recognition of a polyubiquitin chain on the substrate by one or more ubiquitin-binding subunits in the ATPase subcomplex. For substrates of the other ...

Park's laboratory studies the biogenesis of a molecular machine known as the proteasome, a major protease in eukaryotes. Her studies have changed the traditional view of the spontaneous formation of ...

The prize was for the determination of the detailed mechanism by which ATP shuttles energy. The enzyme which makes ATP is called ATP synthase, or ATPase, and sits on the mitochondria in animal cells ...

The prize was for the determination of the detailed mechanism by which ATP shuttles energy. The enzyme which makes ATP is called ATP synthase, or ATPase, and sits on the mitochondria in animal cells ...

Proton pump inhibitors are a class of medications used to treat conditions like GERD and ulcers. They work by blocking the ...

RP-3467 is Repare’s fourth clinical program. “RP-3467, our potential best-in-class Polθ ATPase inhibitor, has demonstrated highly compelling preclinical results, including complete and ...

Repare Therapeutics has dosed the first subject in its Phase I POLAR clinical trial of RP-3467, a Polθ ATPase inhibitor, as a ...