Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression. They are non-integrating vectors so expression in dividing cells is progressively lost. First ...

As the particles are often pseudotyped with the envelope of the vesicular stomatitis virus (VSV), the vector can serve to introduce genes into a broad range of tissues and can be used in vivo.

Current lentiviral vector systems (the third generation) generate virus particles using four plasmids and a producer cell line. The rationale behind four plasmids is to enhance safety, as ...

Figure 1: Lentiviral GDNF delivery is neuroprotective in the monkey Parkinson Disease model. The vector was administered 1 week after the injection of the MPTP toxin; that is, after the monkeys ...

Lentiviral vectors, derived from HIV-1 ... Notable examples include the development of Ebola and COVID-19 vaccines using adenoviral and other viral vector platforms. As the field of viral vector ...

The popularity of viral vector-based gene therapies and vaccines is rapidly growing ... Download this application note from Thermo Fisher Scientific to learn how scientists have used their lentiviral ...

Ever since recombinant DNA has been used to develop and manufacture vaccines, antivaxxers have portrayed it as evil. This ...

Pell's commitment to advancing cell therapies extends beyond its own pipeline. Its subsidiary company, Taiwan Cell Manufacturing Company Ltd. (tcmc) offers high-quality lentiviral vector and CAR-T ...

In one of the largest private rounds raised by an Italian biotech, Genespire Srl has closed a €46.6 million (US$51.88 million) series B, enabling it to lay the ground for a phase I/II clinical trial ...

The company collaborates with pharmaceutical and biotechnology companies providing viral vector development and manufacturing services in lentivirus, adeno-associated virus, adenoviral vectors ...