Administration of MSE to HFD mice increases the expression of DsbA-L and the amount of activated adiponectin in the body, and significantly improves diabetic symptoms such as increased fat ...

Wild-type ADP, globular ADP, Cys36Ser ADP, the tail domain of ADP, or leptin was administered i.c.v. (3 µg) in C57Bl/6J mice. Control mice received PBS. Food intake and body weight were measured ...

Wondering whether PAQR4 might also interact with adiponectin to provide health benefits, the researchers investigated its role by genetically modifying lab mice so that they overproduced PAQR4.