Importantly, SIRT1 and USP7 regulate the activity ... In addition to PI3P lipids, activation of AKT/PKB requires phosphorylation on a specific residue by the phosphoinositide-dependent kinase ...

But the activity of AKT itself is also switched on through phosphorylation by other protein kinases. In the early 2000s, scientists had established that the AKT protein is activated by two separate ...

BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by survival factors. Several major signalling pathways influence cell death through their direct effects on the ...

Coagulation factor X performs its' function through increasing the phosphorylation and activation of ERK1/2 (ERK can also enhance the angiogenesis of the tumour) and AKT in macrophages. After that, ...

310 (2023) 116418]. Sargentodoxa cuneata and Patrinia villosa extract inhibits LPS-induced inflammation by shifting macrophages polarization through FAK/PI3K/Akt pathway regulation and glucose ...