Alpha-1 antitrypsin deficiency (AATD ... This results in progressive liver disease secondary to AAT polymerization and accumulation, and chronic obstructive pulmonary disease (COPD) due to ...

The recent conference, `Alpha 1-antitrypsin deficiency and other conformational ... protein structures associated with conformational disease was a major focus of the meeting.

However, no approved therapies exist for AATD-related liver disease, often leading to ... Pi*ZZ AATD do not naturally produce wild-type alpha-1 antitrypsin (M-AAT) protein. Thus, detecting the ...

According to Asthma + Lung UK, there are nearly two million people living with COPD in the UK. “There are 1.7 million people ...