Recent genome-wide analyses of alternative splicing indicate that 40–60% of human genes have alternative splice forms, suggesting that alternative splicing is one of the most significant ...

RNA可变剪接 (Alternative ...

and sites of RNA methylation, to mention a few. It is now clear that regulation of alternative splicing has a huge impact on gene function and there is a great deal to learn about questions ranging ...

日前，我校药学院金汉永副教授在揭示转运RNA（tRNA）片段的生物发生机制及细胞如何利用tRNA片段应对内质网应激（ER stress）方面取得了重要突破，并以第一作者身份在《自然-通讯》（Nature Communications）发表最新研究成果 ...

*仅供医学专业人士阅读参考常看今日说法之类节目的估计都知道，很多犯罪团伙是“家族式”的，基于各种亲情关系一起为非作歹，这就很像人体内的两种现象，一种是多个治疗靶点归属同一个家族，比如同属表皮生长因子受体家族的EGFR和HER2，另一种就是mRNA层面 ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

Remix Therapeutics (Remix), a clinical-stage biotechnology company developing small molecule therapies to modulate RNA ...

Detailed map of the spliceosome is being made publicly available to help researchers pinpoint exactly where splicing errors ...

Biogen has been involved in RNA splicing research since its earliest ... The antisense oligonucleotide works by modulating alternative splicing of the SMN2 exon which is mutated in the disease.

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...