Goldstein and his colleagues studied the role of amyloid precursor protein (APP), which gives rise to the abnormal amyloid clumps ... When something goes wrong with this transport process, the cell ...

which hinges on the premise that abnormal processing of a protein called amyloid precursor protein and accumulation of its byproduct, called beta-amyloid, causes Alzheimer's. Notably, drugs that ...

Amyloid beta (Aβ) peptide, a 40-42 amino acid protein cleaved from the amyloid precursor protein (APP ... whether Aβ is part of the biochemical process that causes the loss of function ...

An international collaboration led by RIKEN researchers has discovered how unusual spherical structures form in the brains of ...

They showed how communication between cellular compartments essential for waste disposal and calcium storage is disrupted by a fragment of the amyloid precursor protein (APP), known as APP-CTF.