Goldstein and his colleagues studied the role of amyloid precursor protein (APP), which gives rise to the abnormal ... When something goes wrong with this transport process, the cell often cannot cope ...

Amyloid beta (Aβ) peptide, a 40-42 amino acid protein cleaved from the amyloid precursor protein (APP ... whether Aβ is part of the biochemical process that causes the loss of function ...

An international collaboration led by RIKEN researchers has discovered how unusual spherical structures form in the brains of ...

A new review was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), on ...

which hinges on the premise that abnormal processing of a protein called amyloid precursor protein and accumulation of its byproduct, called beta-amyloid, causes Alzheimer's. Notably, drugs that ...

“Current approved therapies for ATTR target precursor protein production, reducing the formation of new amyloid, but there is a significant unmet need for new therapies that can remove the existing ...

“To understand the neurodegenerative process in AD ... mice developing Tau pathology and in primary neurons from amyloid precursor protein (APP)–Tau double transgenic mice treated with ...