Studies in three different transgenic mouse models suggest that the amyloid β-protein contributes to memory loss in Alzheimer disease. Immunization with an amyloid β-peptide fragment reduces ...

1Missense mutations in the β-amyloid precursor protein (APP) or the presenilin ... mixtures of Aβ 1–42 and Aβ 1–40 (or fragments thereof), longer in vivo exposures, and other radioisotopes ...

They demonstrated that a fragment of the amyloid precursor protein (APP), called APP-CTF, disrupts communication between cellular compartments crucial for calcium storage and waste disposal ...

Diagnosis and monitoring of sporadic Alzheimer's disease (AD) have long depended on clinical examination of individuals with end-stage disease. However, upcoming anti-AD therapies are optimally ...

Amyloid fibrils appear in many neurodegenerative diseases, and scientists are eager to understand how they form and spread. But amyloids—clumped aggregations of misfolded proteins—can be ...

elegans nematode, to screen for compounds that can stop the growth of amyloid proteins. Through their own screen of over 2,500 compounds, the team found 40 that demonstrate the ability to inhibit ...

In contrast, these tangles are rare in non-human primates and typically confined to small regions of the brain. Clumps of ...

A new review was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), on ...

But U.S. regulators have in recent years approved similar medicines that can reduce levels of the protein, called amyloid, in patients’ brains and that in trials modestly slowed the worsening of ...