They demonstrated that a fragment of the amyloid precursor protein (APP), called APP-CTF, disrupts communication between cellular compartments crucial for calcium storage and waste disposal ...

Clumps of protein fragments derived from amyloid precursor protein, found in the brains of Alzheimer’s patients. These ...

This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).

Diagnosis and monitoring of sporadic Alzheimer's disease (AD) have long depended on clinical examination of individuals with end-stage disease. However, upcoming anti-AD therapies are optimally ...

Studies in three different transgenic mouse models suggest that the amyloid β-protein contributes to memory loss in Alzheimer disease. Immunization with an amyloid β-peptide fragment reduces ...

Amyloid fibrils appear in many neurodegenerative diseases, and scientists are eager to understand how they form and spread. But amyloids—clumped aggregations of misfolded proteins—can be ...

Cardiac amyloidosis is a rare condition defined by the abnormal production of proteins that bind together to form amyloid proteins. These amyloids can gather in different organs throughout the ...

1Missense mutations in the β-amyloid precursor protein (APP) or the presenilin ... mixtures of Aβ 1–42 and Aβ 1–40 (or fragments thereof), longer in vivo exposures, and other radioisotopes ...

But U.S. regulators have in recent years approved similar medicines that can reduce levels of the protein, called amyloid, in patients’ brains and that in trials modestly slowed the worsening of ...

The drugs attack so-called amyloid plaques in the brain. But how can we reliably and cost effectively diagnose the presence of amyloid plaques in patients who show up at memory clinics with slight ...