引言当下火热的CRISPR-Cas基因编辑工具源自原核生物的适应性免疫系统：细菌借助CRISPR-Cas系统对抗噬菌体等病毒的侵染。与此同时，病毒也借助抗CRISPR蛋白（Acrs）等各类“武器”以拮抗CRISPR系统活性【1】。近年来研究者借助序列 ...

The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas) system evolved in bacteria to restrict horizontal gene transfer and as a defense mechanism ...

本报讯（记者孟凌霄）中国科学院生物物理研究所研究员王艳丽团队与加拿大多伦多大学教授Alan Davidson团队合作，揭示了新型anti-CRISPR蛋白——AcrIF25 ...

While the Nobel-winning genome-editing technology CRISPR holds great promise, Duke’s Center for Advanced Genomic Technologies ...

Proteins are biopolymers of amino acids (polypeptides), joined by peptide bonds, that are generated by ribosomes. The amino acid sequence, encoded by its gene, determines a protein’s structure ...

Caption This image shows how the CRISPR surveillance complex is disabled by two copies of anti-CRISPR protein AcrF1 (red) and one AcrF2 (light green). These anti-CRISPRs block access to the CRISPR ...

In addition, CRISPR-Cas9 sometimes makes mistakes and docks at other sites in addition to its target sequence. For this reason, researchers would like to modify the system to ensure that such misses ...

Labroots invites you to the 7th Annual Event in the CRISPR Virtual Event Series 2024 taking place on October 23rd, 2024! This event will continue the conversation of the abilities of CRISPR-based ...

A new gene-editing protein, CasX, may give CRISPR-Cas9 a run for its money. Scientists have determined the unique structure of CasX, revealing that this pint-sized Cas enzyme is dominated by RNA that ...

Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12 ...

The cryogenic electron microscope structure of the A4p-activated (green) CalpL protein filament (violet) from Candidatus Cloacimonas acidaminovorans (PDB ID: 9EYJ). CRISPR-Cas systems help to ...