Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.

These findings in the human are at the basis of our proposed structure-function model in which the antigen binding features of the germline template antibody are dictated by the somatically ...

As part of an international collaboration, Fred Hutch scientists provided structural information that helped reveal how two ...

Antibodies are Y-shaped proteins that reach out to their targets with the tips of each arm. If the antibody interacts with a ...

Scientists have created a novel technology for developing antibody (M6P) conjugates without enzyme modification in vitro, ...

This implied that the antibodies made the CADM1 proteins relocate to a different, more stable cellular structure—one which was not dissolved by standard detergents used during lipid and protein ...

Over 100 designed proteins were validated, showing high accuracy in structure and functionality. The method scales to large ...