Antifungal development is inherently difficult ... that pose the greatest threat to public health—a list that included azole-resistant Aspergillus fumigatus. The fungicides used to protect ...

Second, there is a greater chance of drug interactions. Azole antifungals (e.g., fluconazole, itraconazole and voriconazole) alter metabolism of cyclophosphamide, a cytotoxic agent, through ...

The study suggests that bisphosphonates could be repurposed to use with azole antifungals, which are relatively nontoxic, and that the combination could be readily tested in clinical studies.

Only four classes of antifungal drugs currently exist, and pathogen resistance to these medications complicates treatment. A research team has identified the resistance mutations of the fungus Candida ...