What if cancer cells became their own enemies? A team from Stanford seems to have found a way to achieve this goal. In our ...

Our bodies divest themselves of 60 billion cells every day through a natural process of cell culling and turnover called ...

Scientists working in a lab. Image source: chokniti / Adobe One of the main proteins used in the new procedure is called BCL6, and when it mutates, it actually drives blood cancer. Medical ...

Flipping the cancer script One of these proteins, BCL6, when mutated, drives the blood cancer known as diffuse large cell B-cell lymphoma. This kind of cancer-driving protein is also referred to as an ...

史丹佛大学的科学家发展出一项创新技术，将2种蛋白质结合以诱导癌细胞自毁，为血癌治疗带来新契机。透过模仿细胞自然凋亡机制，研究团队利用一种特殊分子将癌细胞内的蛋白质连接在一起，使其启动细胞死亡基因，促使肿瘤细胞自我破坏，这项研究已于10月4日发表在《科学》（Science）期刊上。这项技术源自 ...

They found that one protein, BCL6, facilitates blood cancer when mutated and is responsible for halting apoptosis in cancer cells, allowing them to continuously live and divide uncontrollably.

In a new study, the research team describes how the degrader selectively sticks to the BCL6 protein – a protein which B-cell lymphoma cells need to survive – and tags it to be destroyed. BCL6 binds to ...

Image: the BCL6 BTB domain dimer (in grey/green) and compound hits in pink, superimposed on each other in the main compound binding site. Dr Rob van Montfort lab / ICR Scientists have revealed details ...

Sarott et al. set out to repurpose these CDK inhibitors as chemical inducers of proximity (CIPs) that activate genes repressed by the DNA-binding transcription factor BCL6. This oncoprotein ...