Inhibiting bone resorption via an effect on the RANK/RANKL/OPG signaling pathway (see following section); Enhancing bone formation by prolonging the lifespan of osteoblast cells (Figure 1A).

“Mechanistically, hyponatremia-induced bone resorption and osteoporosis is unique in that it represents an attempt of the body to preserve sodium homeostasis at the expense of bone structural ...

Osteoporosis is a disabling skeletal disorder that is characterized by decreased bone strength, predisposing patients to increased risk of bone fracture. Peak bone mass (maximum bone strength and ...

Current therapies for the prevention and treatment of osteoporosis are limited by efficacy and patient compliance. RANKL/osteoprotegerin/RANK signaling regulates bone resorption and is essential ...

Dr Akhilesh Yadav, Associate Director- Orthopaedics and Joint Replacement, Max Hospital Vaishali explains when bones have osteoporosis, they become porous, brittle, and more prone to breaking. When ...

Osteoporosis is a common bone disorder characterized ... Melatonin signaling normally promotes bone formation and inhibits ...