The irreversibility of cell-cycle transitions is commonly thought ... is initiated by Cdk1–CycB complexes in yeasts (Cdk1–Clb5,6 in budding yeast; Cdk1–Cig2 in fission yeast).

An international team led by researchers at the University of Toronto has mapped the movement of proteins encoded by the ...

A study led by the University of Toronto has just seen the movement of proteins encoded by the yeast genome mapped throughout its cell cycle successfully. The process of monitoring all the ...

In this regard, we focus on a conserved multiprotein complex that includes Mre11, Rad50, and Nbs1 in mammals or Xrs2 in the budding yeast S. cerevisiae ... Our data suggest that in human cells, the ...

the working parts of living cells. A recent study that shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new approach to combatting drug resistance ...

Our demonstration of a potent anti-tumor effect of lithocholic acid in cultured human cancer cells and our identification of the mechanisms underlying such effect of lithocholic acid has been ...

"Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico."Mol Syst Biol. 2011 Dec 6;7:556. doi: 10.1038/msb.2011.91. (9) Kazukari Kaizu, Hisao Moriya, and Hiroaki Kitano ...

The story of the cell cycle is often told only through the perspective of the chromosomes as they replicate and then divide. This resource beautifully illustrates the role of the cytoskeleton in that ...

"One of the fundamental questions of life replication is: what is the mechanism that allows this structure (the CENP-A marker) to exactly restore itself at every cell cycle?," says Prof.

When looking at cells with a microscope, the length of different stages of the cell cycle can be estimated using the formula: \(\text{Length of time in phase}=\) \(\frac{\text{observed number of ...