In other experiments, it seems as if there are steric effects such that as long as the CD8 mAb is labeled with PE (240 kDa), the non-antigen specific effects are abrogated. When CD8-mediated binding ...

26 in Nature Immunology, the researchers discovered that activating a metabolic pathway called the pentose phosphate pathway makes antitumor CD8 T cells more likely to stay in an immature ...

Opens in a new tab or window Significantly more patients with moderately to severely active ulcerative colitis achieved clinical remission with the investigational monoclonal antibody tulisokibart ...

Liver toxicity was observed with anti-4-1BB mAb but not with the ABL106T×4-1BB ... of regulatory T cells and enhanced functionality of CD8 TILs. These results show that ABL403 works as a novel ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window The investigational monoclonal antibody clesrovimab protected against respiratory syncytial virus (RSV) disease and ...

Figure 1. Isothermal denaturation and subsequent aggregation of a mAb vs. time from 65 °C–83 °C. Aggregation is represented by changes in relative molecular weight (Mw/Mo). Figure 2 depicts ...

EGFR: EGF receptor; mAb: Monoclonal antibody; VEGFR: VEGF receptor. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in ...

Retraction Note: M2 macrophage-derived extracellular vesicles promote gastric cancer progression via a microRNA-130b-3p/MLL3/GRHL2 signaling cascade. Retraction Note ...

在免疫学的广阔领域中，PD-1（程序性死亡受体1）与PD-L1（程序性死亡配体1）作为关键的免疫检查点分子，对免疫系统的调节与平衡起着至关重要的作用。近年来，随着对肿瘤免疫逃逸机制的深入研究，PD-1与PD-L1在肿瘤微环境中的作用受到极大关注。本文 ...

This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for ...