Pyruvate-mediated GPR31 activation enhances human intestinal conventional type 1 dendritic cell (cDC1) function by facilitating transepithelial dendrite formation, which improves the uptake of gut ...

The dendrites, when extended out, help dendritic cells sample the gut for ... In the presence of pyruvate and GPR31, the cDC1 cells were better at detecting antigens and bacteria, like E.

The article is titled "Pyruvate–GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells." When they tested how different metabolites affected cDC1 cells ...

The dendrites, when extended out, help dendritic cells sample the gut for foreign substances ... In the presence of pyruvate and GPR31, the cDC1 cells were better at detecting antigens and bacteria, ...

Myelopoiesis is the process in which innate immune cells, such as neutrophils, dendritic cells and monocytes, develop from a myeloid progenitor cell. The Irf8 +32-kb enhancer controls ...

An attenuated, cis-targeted interferon, ORB-011 precisely activates cDC1 dendritic immune cells. These cells are said to be tumour cell-destroying CD8+ T cell activators. According to preclinical ...

Now, researchers from Osaka University have discovered that one receptor, called GPR31, is active in a specific type of immune cell found in the gut, known as conventional type 1 dendritic cells ...