The concept of 'checkpoints' arose from the discovery of genes in budding yeast that are required for coordinating the progression of cell-cycle events when earlier processes have not been ...

The cell must also pass through a series of checkpoints that ensure conditions are favorable for division. In order to move from one phase of its life cycle to the next, a cell must pass through ...

CHK1 is important for the activation of S, G2 checkpoints in response to DNA damage and replicative stress and is involved ... and concept for the project that CHK1 inhibition was therapeutically ...