Cholestasis is characterized by the accumulation of bile acids (BAs) in the liver and is often associated with severe itching (cholestatic pruritus (CP)). Activation of the GPCR hX4 in dorsal root ...

Cholestasis is a liver condition that sometimes develops in late pregnancy – and the first symptom is extreme itchiness.

Glucocorticoid anti-inflammatory effect *Cholestyramine is not as effective as ursodeoxycholic acid in reducing pruritus. Women treated with cholestyramine should be given supplemental fat soluble ...

Gilead Sciences, Inc. (Nasdaq: GILD) today announced that the Committee for Medicinal Products for Human Use (CHMP) of the ...

It is also approved in the U.S. for the treatment of cholestatic pruritus in patients with progressive familial intrahepatic cholestasis (PFIC) 12 months of age and older and in Europe for the ...

Odevixibat is a once-daily non-systemic ileal bile acid transport (IBAT) inhibitor approved under the brand name Bylvay ® in the U.S. as the first drug treatment option for patients 3 months of age ...

Rapid initial pruritus scores achieved by week 4 were ... with cholestatic pruritus due to progressive familial intrahepatic cholestasis (PFIC). BYLVAY may not be effective in a subgroup of ...

Ipsen is committed to being the leader across rare cholestatic liver diseases and we are just getting started.” “These open-label extension data from PEDFIC 2 suggest that the initial reduction in ...