It may be used in combination with other acne treatments. Clindamycin is used to treat a wide variety of bacterial infections. Spironolactone is used to treat high blood pressure and heart failure.

2001). A recent study demonstrated that a fixed combination of topical clindamycin 1%/benzoyl peroxide 5%, along with tretinoin microsphere gel (0.04% or 0.1%) or adapalene 0.1% gel, improved ...