Of note, adverse effects and tolerability were comparable in the adapalene-BPO vs adapalene 0.1% gel groups. Currently marketed combination products include BPO-clindamycin and clindamycin ...

It may be used in combination with other acne treatments. Clindamycin is used to treat a wide variety of bacterial infections. Spironolactone is used to treat high blood pressure and heart failure.