(2001) demonstrated that the budding yeast protein Mrc1 is the replication checkpoint transducer ... However, prolonged RF stalling leads to DNA damage; alternatively, the fork may collapse ...
Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...
By using an existing test tube model developed for budding yeast, scientists at The Institute of Cancer ... “We found that telomere DNA has no real effect, or a very weak effect on DNA replication.
The findings visualize for the first time a molecular complex—called CTF18-RFC in humans and Ctf18-RFC in yeast—that loads a "clamp" onto DNA to keep parts of the replication machinery from ...
Colorado State University has identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast Researchers at Colorado State ...