We identify drug metabolites from liver microsomes (e.g., mouse, rat, dog, and human) and in vivo studies. Identifying the unstable moieties can help guide the synthetic optimization of lead compounds ...

These tiny carriers are packed with a synthetic thyroid hormone drug called a thyromimetic. While thyroid hormones are ...

How Timely Screening of liver function tests can prevent the development of underlying serious health diseases.

Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological ... as they discuss the current understanding of the mechanisms that contribute to DILI and how ...

“As diabetes compromises drug treatment ... where he found that liver glucose metabolism was also disrupted when people progressed to TB from latent infection. Professor Cooper added ...

liver function can impact the drug’s metabolism. If the drug’s metabolism is affected by poor liver function, the drug may take longer to leave the body, resulting in prolonged effects. Age can play a ...

Liver failure encompasses a range of severe clinical syndromes resulting from the deterioration of liver function, triggered ...

This research explores how alcohol consumption disrupts metabolism, damages the liver, and impairs male reproductive health, ...

Characterized by excessive fat accumulation in the liver, this condition poses significant risks for various metabolic disorders. While much of the existing research has focused on fat metabolism ...

My NIH-funded research started with a focus on developing advanced chemical biology approaches to understand enzyme/protein ...

An antibody called bFKB1 improves liver disease ... by the U.S. Food and Drug Administration to treat the condition. In previous animal tests, bFKB1 improved metabolism and decreased body weight ...