Exocytosis is the process by which cytoplasmic secretory vesicles fuse with the cellular membrane, releasing contents to the extracellular space. The extrusion of large extracellular vesicles is ...

Luteolin acts as a powerful drug that enhances the detoxification of DEHP by targeting Uroc1 in the mouse liver, thus ...

Environmental pollution is a major health problem that affects the health of individuals worldwide and is cumulative with ...

Carbonic anhydrase inhibitors show potential in reducing tau protein buildup, offering new therapeutic avenues for neurodegenerative diseases like tauopathies.

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has ...

CA inhibition abrogates lysosomal acidification and causes tau secretion by lysosomal exocytosis without having a prion effect. This mechanism lowers intracellular tau and is neuroprotective in ...

NK 3.3 cells are CD3-, CD4-, CD8-, CD2+, CD16+, CD56+. They are capable of strong NK cell lysis of sensitive target cells. NK 3.3 cells have been shown to kill by both perforin/granzyme mediated ...

A preclinical study is revealing new insights into the molecular machinery that drives the aggressiveness of pancreatic ...

A preclinical University of Toronto study is revealing new insights into the molecular machinery that drives the aggressiveness of pancreatic cancer. This cancer’s ability to invade and spread to ...

In secretory cells such as gonadotropes, the cytoplasmic face of the plasma membrane is associated with a dense meshwork of actin filaments (termed cortical actin) and actin binding proteins that play ...

After attachment and subsequent fusion with the host cell membrane, the enveloped mpox virus leaves the infected host cell ...

Protein contact dermatitis is an allergic skin reaction induced principally by proteins of either animal or plant origin. The clinical presentation is that of a chronic dermatitis, and it is often ...