Bitter taste receptor has hidden intracellular pocket that enables activation via simultaneous extracellular/intracellular ...

"Tasting Upside-Down - An Unusual Sensing Mechanism was Found in Human Bitter Sensing" A new study revealed that some bitter ...

EpiBiologics, a leader in tissue-selective extracellular protein degradation, will be presenting new data demonstrating the unique capabilities of its ...

For example, membrane receptors bind and respond to specific molecules outside the cell, such as hormones, neurotransmitters, the extracellular matrix, and attachment molecules on other cells.

A new study describes an exciting discovery that changes the way we understand human bitter taste receptors. The research has ...

The structure led to a surprising discovery: the drug binds simultaneously at two distinct positions of the receptor: one copy bound at an extracellular site and the other at the intracellular one.

Receptors are shown as two lobes connected by a transmembrane stretch. Binding of a ligand, neuregulin (NRG, blue square) or something EGF-like to the extracellular lobe activates the receptors.