A number of cell surface and nuclear receptors mediate their actions via dimerization. While this has been well established, the dimerization of G-protein coupled receptors (GPCRs) (that ...
A 2A R is a member of major drug targets G protein-coupled receptor (GPCR) superfamily, which engages the G protein and initiates cell signaling, influencing heart health, inflammation ...
The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...
AHA 2024 Presentation Details (being held in Chicago, IL, Nov 16-18, 2024): Title: The tolerability, safety, pharmacokinetics, and pharmacodynamics of TX000045, a long-acting Fc-relaxin fusion protein ...