Recent genome-wide analyses of alternative splicing indicate that 40–60% of human genes have alternative splice forms, suggesting that alternative splicing is one of the most significant ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

Researchers unveil the inner mechanisms of the most intricate and complex molecular machine in human biology. Scientists at the Centre (CRG) in Barcelona have developed the first comprehensive ...

Detailed map of the spliceosome is being made publicly available to help researchers pinpoint exactly where splicing errors ...

During splicing, non-coding segments of RNA are removed, and the remaining coding sequences are stitched together to form a template or recipe for protein production. While humans have about 20,000 ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular ...

A new study helps explain the role of genetic variation in shaping gene regulation in the Indonesian archipelago, one of the most diverse regions in the world. “This study is the only study of ...

The outline of this labyrinthine cellular machinery, the most complex in humans, opens up new ways of designing treatments ...

Tumor suppressor mutations typically involve indels, splicing, or nonsense mutations distributed throughout the gene. The TP53 gene ... of missense p53 variants in human tumors may have clinical ...