So far, the best-characterized function of VHL has been as a component of an E3 ubiquitin ligase complex, which mediates degradation of the hypoxia-inducible factor (HIF) under normoxic conditions.

The Branin, or Branin-Hoo, function has three global minima. The recommended values of a, b, c, r, s and t are: a = 1, b = 5.1 ⁄ (4π 2), c = 5 ⁄ π, r = 6, s ...

Authors should provide at the time of submission a short paragraph explaining why their work justifies urgent publication as a Communication. Ideally, a Full paper in Food & Function should follow ...

During hypoxia, β-catenin is displaced from TCF-4 (which results in TCF-4 repression) via its interaction with HIF-1, and β-catenin enhances HIF-1 transcriptional activity. In addition, COX-2 is ...

Studies have shown that the factors that promote the healing of diabetic foot ulcer are related to inhibiting apoptosis, promoting fibrocyte proliferation, promoting angiogenesis, accelerating ...

Executive function describes a set of cognitive processes and mental skills that help an individual plan, monitor, and successfully execute their goals. The “executive functions,” as they’re ...

Recent research highlights the potential of targeting the brain’s metabolism to treat Alzheimer’s disease, a condition that ...

A function is a way of describing what happens to an input variable, in order to get the output result. \(\text{Input} \rightarrow \text{FUNCTION} \rightarrow \text{Output}\) If we think of a ...

The inverse function for \(f(x)\) is written as \(f^{-1}(x)\). To find an inverse function, form an equation by giving the output value a name using a letter (such as \(y\)), then rearrange the ...

The rumen microbiota—a symbiont to its host and consists of critical functional substances—plays a vital role in the animal ...

HIF has a Low complaints rating. When we score policies we give each fund a complaints ... In the Northern Territory this fund has... 1 private hospital agreement out of an industry maximum of 1. 2 ...