The cells died in the most dangerous versions. The researchers discovered that the defective VHL gene elevated the activity of the HIF gene. While an excess of HIF protein can result in tumors ...

As a result, this protein can bind to HIF1β and facilitate gene transcription of many HIF target genes (Figure 1; Schofield & Ratcliffe, 2004). Some organisms, like the roundworm C. elegans ...

Mutations in the responsible gene rob cells of a normal version of ... unlike normal cells, cannot destroy HIF when oxygen is present. Both Kaelin and Ratcliffe then showed that the binding ...

Sep. 25, 2024 — Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the new results of an ...

Nine companies joined The Crunchbase Unicorn Board in September, taking the board to just shy of 1,550 companies and $5.2 ...

Sep. 16, 2024 — CREME is a virtual laboratory that allows scientists to simulate specific decreases in gene activity. It offers a powerful new tool for identifying and understanding important ...

Gene therapy and gene editing are on the cutting edge of modern biotechnology. Gene therapies are used to correct genetic abnormalities by introducing genetic material at a cellular level and can ...

Current scientific techniques are not yet safe or effective enough to be used to create gene-edited babies, an international committee says. The technology could one day prevent parents from ...

After that, the next step in CRISPR gene editing is usually to alter that piece of DNA. However, CRISPR has also been adapted to do other things too, such as turning genes on or off without ...

Gene Park is a reporter for The Washington Post, covering video games and gaming culture. He joined The Post in 2015 as audience editor, and is a former reporter in the West Coast and Pacific region.