The cloning of human TPO in 1994 paved the way for the ... stimulation of c-Mpl may potentiate platelet activation and trigger thrombosis, a particular concern for older patients with co-existent ...

[97–99] There are two main causes for the bacteria-induced thrombocytopenia: Bacteria induce platelet activation. Activated platelets show shortened survival and are targets of phagocytic ...