and ulcers are its most serious complication. Beginning with neuropathy, the subsequent foot wounds frequently lead to lower extremity amputation, even in the absence of critical limb ischemia.

Meanwhile, there are very few therapies available for ischemic foot ulcers in diabetes. No medication is known to reduce ischemic lower extremity ulceration, according to Pradhan's group.

Mean calculated using the mixed-effects model for repeated measures; differences were not statistically significant, as expected given that the study was not powered to show efficacy.