(D, E) The expression of MYC regulated genes related to cell cycle and EMT in LINC00901 overexpression (D) or KO cells (E) was detected by qRT-PCR. Values are mean ± S.D., n = 3; ∗∗P 0.01.

ACB’s pipeline is led by an oncogene-enabled synthetic lethality program, MYC-SL, that is focused on targeting cells with overexpression of MYC, and a drug combination to restore contact ...

A group of researchers led by Alexander Tonevitsky, Dean of the Faculty of Biology and Biotechnology at HSE University, have ...

However, the study published Aug. 28 in Nature Communications identifies the MYC gene as a common denominator across prostate cancers. The work demonstrates that initial MYC activation attracts ...

Background: Variable rates of HER2 protein overexpression and gene amplification have been reported in advanced ovarian cancers (AOC). Trastuzumab, tested only as a single agent, has been shown to ...

The disease is associated with Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), and chromosomal translocations that cause the overexpression of oncogene c-myc. Ms Juliet Boateng ...

Whether the mutation alters outcome of hormonal therapies, in specimens from a clinical trial, and in a bitransgenic mouse models crossing the mutant with c-myc and HER-2 oncogene ... We plan to ...

Many diseases, including cancer, stem from aberrant activation or overexpression of proteins that rewire multiple ... successfully demonstrated c-MYC and brachyury degradation in both cells and animal ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

The work presented will be of interest to cancer biologists and more broadly to those interested in NSCLC translational studies. Non-small cell lung cancer (NSCLC) is the most common subtype of lung ...