衰老或会损伤机体的抗肿瘤 免疫 力，但其发生背后的分子机制，研究人员并不清楚。近日，一篇发表在国际杂志 Nature Aging 上题为 “Age-related decline in CD8+ tissue resident memory T ...

伴随着衰老过程，人类患癌症风险上升。普遍认为，个体衰老进程导致DNA损伤和原癌基因激活，进而诱导细胞发生癌前病变。有研究提出，免疫衰老是衰老个体共有的生理现象。免疫衰老是伴随年龄增长出现的免疫系统的退行性改变，是导致个体“免疫力”下降进而诱发包括肿瘤 ...

A research team from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences has revealed ...

12月5日，山东第一医科大学第一附属医院（省千佛山医院）肿瘤中心叶欣团队的研究性论著《Microwave Ablation Combined with Flt3L Provokes Tumor-Specific Memory CD8+ T Cells ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

The scAtlasVAE model integrates scRNA-seq data to create a CD8+ T cell atlas, enhancing understanding of immune responses in ...

该研究发现，衰老会导致双功能凋亡调节因子（BFAR）在CD8 + T细胞中高度富集，而BFAR作为一种E3泛素连接酶，可导致JAK2激酶的去泛素化，从而抑制 ...

US biotech Nektar Therapeutics has announced results of its Phase II proof-of-concept study of NKTR-255 as an adjuvant ...

In a study published in Nature Aging on Nov. 26, a research team from the Shanghai Institute of Nutrition and Health (SINH) ...

Nektar Therapeutics announced promising results from a Phase 2 study of its experimental drug NKTR-255, which improved ...

Raynor et al, CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident ...