bile acids accumulate due to disrupted metabolism. Up to 80% of cholestasis patients experience severe itching (pruritus), significantly impacting their quality of life. However, the molecular ...

A diverse complement of amino acids are conjugated to bile acids by bacteria, and the resulting MCBAs have very different chemical properties. For example, we have evidence that if bacteria use a ...

Recent advances in the molecular cloning of membrane transport systems that determine bile formation have facilitated studies of the molecular mechanisms of cholestatic liver disease. The present ...