Preliminary data suggest leveraging γδ T cells’ natural ability to target malignancy-induced NK group 2D (NKG2D) stress-associated antigens on tumor cells, with the addition of a non-signaling ...

As such, NKG2D-based CAR-T cells could potentially address the vast majority of hematological malignancies and solid tumors. In addition, preclini-cal studies have shown that NKG2D CAR-T cells may ...

The NKG2 (CD159) family of proteins includes NKG2D and NKG2A ... MHC class I molecule HLA-E on target cells. This interaction prevents the triggering of T cells and NK cells through the tyrosine ...