Electron microscope image of synapse in the cerebellum. This slice through the cerebellum cells shows the synapse between an inhibitory neuron (red) and a Purkinje cell (yellow). There ...
“What you can now do”, Roska says, “is look simultaneously at all 150-200 presynaptic neurons that give input to your postsynaptic neuron and ... laser path of a 2P microscope.
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This microscope called the RUSH3D system offers ... stimulation and tracked large-scale neural responses with single-neuron precision across several consecutive days, according to the study.
He laid the foundation with a little background, establishing that we’ve been able to see individual static neurons for a while via microscope ... out how it works one neuron at a time.
Live imaging at single-vesicle resolution reveals rabphilin-3A as the first identified negative regulator of neuropeptide release in mammalian neurons.