Osteoclastic bone resorption is regulated by the RANKL/osteoprotegerin/RANK pathway ... Canonical Wnt signaling regulates bone formation and is essential for osteoblast proliferation ...
Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...
Novel regulatory pathways linking fat mass ... Therapeutic targeting of RANKL/OPG/RANK signaling. Osteoclasts express RANK, while osteoblasts express the RANKL and also secrete a decoy receptor ...
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