Novel regulatory pathways linking fat mass ... Therapeutic targeting of RANKL/OPG/RANK signaling. Osteoclasts express RANK, while osteoblasts express the RANKL and also secrete a decoy receptor ...

Similarly, essential genes in the canonical Wnt signaling pathway that are required for osteoblast differentiation have been revealed by investigation of patients with skeletal dysplasias.

Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...