This class of drugs slows bone resorption and thereby increases BMD; however, the precise effect of bisphosphonate therapy on the target cell—the osteoclast—remains elusive. As bisphosphonates ...

Bones are constantly being remodeled through the action of osteoclasts, which break down bone tissue, and osteoblasts, which create new bone tissue. Both cell types develop from immature precursor ...

Multiple myeloma activates cells that break down bone called osteoclasts. This can lead to ... the clonal bone marrow plasma cells are greater than 60% the serum free light chain (FLC) ratio ...