The Greenland shark has by far the longest lifespan for a vertebrate, with an estimated life span of around 400 years.

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked ...

【导读】作为癌症中最常见的基因改变，超过一半的人类癌症具有导致转录失活的p53突变。然而，p53如何调节免疫景观以创造免疫逃逸的生态位，仍然难以捉摸。团队发现癌症干细胞（CSCs）建立了白细胞介素34（IL-34）编排的生态位，以促进p53灭活肝癌的 ...

It causes mutations in the p53 tumor-suppressor gene as well as ras mutations, which are involved in the majority of human cancers. Aflatoxin has been shown to contaminate tobacco products.

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

研究发现了可用于肿瘤干预的p53-SET-PP2A反馈调节环路。研究人员设计联合应用p53激活剂和SET拮抗剂，发现两者能够产生协同抑制肿瘤的生物学效应 ...

Data show that p300 KAT inhibitor KB-9558 was highly selective against human papillomavirus (HPV) oncoproteins E6 and E7, and therefore drove ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

【导读】LACTB在几种肿瘤中被认为是肿瘤抑制因子。然而，初步研究表明，在骨肉瘤中，LACTB过表达，预示预后不良。9月26日，中山大学尹军强教授研究团队在期刊《Advanced Science》上发表了研究论文，题为“SNPs Give LACTB ...

研究还发现，一种名为HDAC7的酶是红白血病发病的关键和特异性调节因子，可促进红白血病细胞生长。研究人员表示，这种酶可作为潜在治疗靶点，若能开发出诱导其分解的药物，或许可用于治疗急性红白血病。