Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...
The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...
A potential new treatment for an aggressive form of prostate cancer has shown promise in lab tests. American scientists have ...
Attractive p53 targets include TP53-induced glycolysis ... which affect genotoxic stress and suppress mTOR (a nutritional sensor known to be affected by diabetes). Starvation also activates ...
Other markers involved in cell propagation and metastasis examined to date are p53, vascular cell adhesion ... mammalian target of rapamycin (mTOR) inhibitors (rapamycin), and the monoclonal ...
high mitotic count and p53 positivity Although responsive to chemotherapy, TNBCs and BLBCs tend to relapse and metastasize early and have a worse prognosis than other tumor subtypes There are no ...
【导读】SETD8是一种在几种癌症中过度表达的甲基转移酶，它使H4K20和其他非组蛋白靶点(如PCNA或p53)单甲基化。9月28日，西班牙国立癌症研究中心研究人员在期刊《Cell Death&Disease》上发表了研究论文，题为“SETD8 ...
A potential new treatment for an aggressive form of prostate cancer has shown promise in lab tests. American scientists have ...
A potential new treatment for an aggressive form of prostate cancer has shown promise in lab tests. American scientists have ...
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