Medivir has developed MIV-818, a prodrug which is cleaved inside the tumor cells to produce the active metabolite TRX-TP. Subsequently, TRX-TP is incorporated into DNA, causing double-strand DNA ...

Expert Rev Clin Pharmacol. 2012;5(3):319-336. Finally, a recent study suggested that although prasugrel significantly reduces thrombotic events in patients with ACS undergoing PCI because of its ...

Researchers from IOCB Prague have succeeded in preparing compounds capable of activating prodrugs at predetermined locations in the body, enhancing their effectiveness and expediting their action.

This shift in focus brings attention to prodrugs – medications that start as inactive or less active, and once inside the ...

Haihe Biopharma Co. Ltd. has published work on the discovery of novel ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibitors being developed for the treatment of cancer.

The current interest in prodrugs is evident. Since 2008, the FDA has approved over 30 prodrugs, and approximately 10% of all marketed drugs worldwide can be considered prodrugs. Consequently, the ...

Thienopyridines should be stopped (clopidogrel for 5 days and prasugrel for 7 days) prior to procedure and aspirin substituted. Thienopyridines will be resumed shortly after the procedure if ...