Dysfunctions of the tiny cell processes (primary cilia*) of the pancreatic beta cells could be a cause of type 2 diabetes.

Insulin resistance often is the primary metabolic abnormality ... leading to delayed and insufficient insulin secretion. Due to decreasing beta-cell function, the individual with insulin ...

Increased levels of glucose in the circulation lead to increased glucose uptake into pancreatic beta ... cell (2); and cell depolarization opens a calcium channel (3) which leads to insulin ...

Insulin secretion primarily takes place in pancreatic beta cells, where one can find defective insulin ... To understand the root causes, diabetes mellitus is bifurcated into two primary categories: ...

Insulin resistance refers to impaired insulin signaling and action at the level of the cell, and the primary ... secretion of each of these hormones depends on specific factors. For example, beta ...

Scientists reprogrammed a woman's fat cells to become insulin-making beta cells, reversing her type 1 diabetes.

Some data suggest that increased apoptosis and decreased regeneration of beta cells are genetically programmed. Exaggerated insulin secretion ... will itself add to the primary therapeutic effect ...