the authors used two different methods to block the activity of the Wnt-PCP signalling pathway in the intercalation region of the chick embryo and showed that intercalation and primitive streak ...

In contrast, the Wnt cascade is activated in the absence ... Joubin and Stern conclude that, during the primitive-streak stages of gastrulation, rather than there being a resident node cell ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...