此外，蛋白在纯化过程中其构象可能发生改变，所获得的药物-靶标相互作用信息不能反映活细胞内的真实情况。而且很多蛋白很难重组表达纯化，进而限制了利用生物物理分子互作技术鉴定化合物和蛋白的相互作用。这时，也可以采用 细胞热迁移技术 (cell ...

Historically, most people started HIV treatment with two drugs from the NRTI class combined with either one NNRTI, one protease inhibitor or one integrase inhibitor – hence, ‘triple therapy’.

This valuable study addresses potential roles of the master regulator of X chromosome inactivation, the Xist long non-coding RNA, in autosomal gene regulation. Using data from mouse cells, the authors ...

This useful study by Gao et al identifies Hspa2 as a heterogeneous transcript in the early embryo and proposes a plausible mechanism showing interactions with Carm1. The authors propose that ...

Fresh fruit and flamboyant garnishes add an element of fun, while some would say serving the right cocktail in the wrong glass takes away its classiness. But cocktail making shouldn’t be a ...

Their new discovery is detailed in the paper, "Design of novel and highly selective SARS-CoV-2 main protease inhibitors," published in the journal Antimicrobial Agents and Chemotherapy.

These make a thoughtful (and colorful) gift for any cocktail enthusiast. Gifting powerhouse Uncommon Goods has a wide range of cocktail classes and packages to choose from. Straightforward online ...

Bring a large pan of water to the boil and add a squeeze of lemon and glug of vinegar. Add the whole prawns and cook until they rise to the surface. Drain and chill in ice-cold water. Peel the ...