Imbalances in pyrimidine biosynthesis can lead to various disorders, such as orotic aciduria and pyrimidine nucleoside phosphorylase deficiency. Some pyrimidine analogs, such as azidothymidine (AZT) ...

Chemotherapy drugs can kill cancer cells by halting DNA replication, but a glucose-depleted environment can help cancer cells ...

Publishing in the journal Nature Metabolism online on November 26 ... Researchers say cancer cells need to run out of ...

Discover how cancer cells survive in low-glucose environments and evade chemotherapy-induced death. New study sheds light on ...

NYU Langone researchers found cancer cells resist chemotherapy in low-glucose environments by conserving pyrimidines and ...

Laboratory experiments with cancer cells have revealed two ways in which tumors evade drugs designed to starve and kill them.

New York: A new research in cancer cells detailed how tumors evade drugs designed to starve and kill them.

The purine structure consists of a pyrimidine ring (positions 1 to 6 ... GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and breakdown ...