RNA splicing is a modification of the nascent ... splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and ...

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that ...

A research team at the Institute of Neurosciences of the University of Barcelona (UBneuro) has led a study describing a new ...

Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya ... We recently solved a 2.2 Å crystal structure of the Candida Trl1 kinase domain in complex with ...

Altered RNA processing is highly damaging to neurons, adding a new toxic component to the evolution of AD. Currently, the ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Since inosine is interpreted as guanosine (G) by the cellular machinery, A-to-I editing can alter codons, splicing sites, and miRNA binding sites ... and structural biology approaches will provide a ...

Defects in RNA splicing or mutations can lead to a wide variety of diseases, ranging from metabolic disorders to cancer. A point mutation occurs when a single nucleotide is erroneously inserted ...

Notable achievements via X-ray crystallography include the first DNA catalyst, the human SF3B complex, and RNA helicase Aquarius. They also revealed the mechanism of splicing modulators (pladienolide, ...

June 24, 2024 — Researchers have harnessed a bacterial immune defense system, known as CRISPR, to efficiently and precisely control the process of RNA splicing ... view of the complex biological ...

The Genomics Institute has awarded grants of up to $50,000 to six multidisciplinary research projects in the inaugural year ...