Figure 1: The immunosuppressive compound rapamycin bound to FKBP12 and the FRB domain of mTOR. Why has a pathway with such florid molecular diversity emerged not once but twice? Only a few of the ...

The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory pathways that have ...

Rapamycin and its analogues do not bind directly ... Phosphorylation of Akt by mTORC2, along with phosphorylation through the PI3K pathway, is required for full Akt activation.

Targeting the phosphoinositide 3 kinase/mammalian target of rapamycin pathway is attractive in HPV-positive and HPV–/p53 wildtype VSCCs. Trials incorporating antibody-drug conjugates (eg, trophoblast ...

Thus far, inhibition of the mTOR pathway has focused on the use of rapamycin, along with three rapamycin analogues: temsirolimus, everolimus, and deforolimus. These agents have been studied as ...

Some scientists say that rapamycin can reduce inflammation "by inhibiting a signaling pathway in the body called mTOR — which ...